Effects of Hypervitaminosis A on Foetal Mouse Bones Cultivated in vitro

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The Reversibility of the Effect of Hypervitaminosis A on Embryonic Limb Bones Cultivated in vitro

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The effect of hypervitaminosis A on embryonic limb bones cultivated in vitro.

T H E skeleton of young animals is profoundly affected by an abnormal amount of vitamin A in the body. In vitamin A deficiency changes in the functional activity of the osteoblasts and osteoclasts allow bone to be deposited in places where it would normally be removed, so producing excessive thickening of certain parts of the skeleton (Mellanby, 1938, 1939). Conversely, excessive vitamin A caus...

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ژورنال

عنوان ژورنال: BMJ

سال: 1950

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.4678.535